Audacious

What files are being fsync()? We only fsync() if the file is writable.

I can't see exactly the files but I see the periodic large fsync() latencies when playing wav file from ssd. Playing wav files from audio cd fsync() latencies occur less often and then only a few ms.

See attached latencytop screenshot.

You're wasting your time and ours asking here about fsync(); it's not called from anywhere in Audacious any more. Look at your screenshot more closely. The 141.3 ms fsync() came from upowerd, not Audacious.